Vladimir A. KASYANOV

Professor, Dr.habil.sc.ing. Vladimir A. KASYANOV (in Latvian - Vladimirs Kasjanovs) Riga Stradins University Institute of Anatomy and Anthropology 16 Dzirciema St., Riga, LV-1007 Latvia Riga Technical University Institute of Biomaterials and Biomechanics Head of Laboratory of Biomechanics Phone: (371) 708-9202, (371) 708 9176 Fax: (371) 747-1815 Email: kasyanov@latnet.lv

Born:  September 10, 1946, Peremyshlyany, Ukraine

Interests:

• Biomaterials, Biomechanics of soft and hard biological tissues
• Biomechanics of cardiovascular system
• Design and fabrication of artificial prostheses for human blood vessels and aortic heart valve
• Cardiovascular tissue engineering

Education:

• M. S. in Civil Engineering, Riga Polytechnic Institute, Riga, Latvia, 1969

Degrees:

• Candidate of Engineering Sciences (Ph.D.). Institute of Polymer Mechanics, Latvian Academy of Science, Riga, 1977
• Doctor of Engineering Sciences (Dr.habil.sc.ing.). Latvian Scientific Research Institute of Traumatology and Orthopedics, Riga, 1989

Academic Certification:

• Professor, Diploma of Riga Stradins University, Riga, 2004
• Doctor of Engineering Sciences (Dr.habil.sc.ing.), Diploma of the Latvian Scientific Council, Riga, 1992
• Doctor of Engineering Sciences (Dr.habil.sc.ing.), Diploma of the USSR Supreme Attestation Committee, Moscow, 1990
• Senior Research Fellow, Diploma of the USSR Supreme Confirmation Committee, Moscow, 1982
• Candidate of Engineering Sciences (Ph.D.), Diploma from the Council of the Institute of Polymer Mechanics, Latvian Academy of Sciences, Riga, USSR, 1977

Experience:

• Engineer, Junior Research Fellow, Senior Research Fellow, Laboratory of Biomechanics, Institute of Polymer Mechanics, Latvian Academy of Sciences, Riga, Latvia, 1971-1988
• Senior Research Fellow, Riga Technical University, Riga, 1988 - 1990
• Head of the Laboratory of Biomechanics, Riga Technical University, Riga, 1990- Present
• Associate Professor, Riga Stradins University, Riga, 1999-2004
• Professor, Riga Stradins University, Riga, 2004 – Present
  

Professional Qualification:

• March – June 2002; October-December 2003; March – May 2004; February – May 2005: Visiting Associate Professor,        Co – investigator in SC NASA EPSCor Research Grant Program: “Cardiovascular Tissue Engineering”.
• August – December 2001: Co - investigator in Florida/Puerto Rico Affiliate of the American Heart Association Grant: “In vitro performance characterization of a novel trileaflet synthetic heart valve”, Florida International University, Biomedical Engineering Institute.
• 2000 and 2001 – Visiting Professor, Cardiovascular Engineering Center, Florida International University, Miami, Florida (National Research Council, Twinning Program 2000 - 2001 With Estonia, Latvia, and Lithuania. Mechanical and hydrodynamic characterization of a novel artificial tri-leaflet aortic heart valve fabricated from composite material).
• 1999: Visiting Coordinator, Research Associate Professor, Cardiovascular Engineering Center, Florida International University, Miami, Florida.
• 1 - 14 August, 20 November - 28 December 1998: Visiting Professor, Department of Cell Biology and Anatomy and Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC.
• 1 February 1998 - 28 February 1998: Visiting Professor, Department of Civil Engineering, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, Wales, UK.
• March 1995-April 1995: Visiting Professor, Department of Civil Engineering, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, Wales, UK.
• June 1994-September 1994: Visiting Professor, College of Textile, Textile Engineering, Chemistry & Science NCSU, Box 8301, Raleigh, NC 27695-830.
• March 1993-May 1993: Visiting Professor, College of Textile, Textile Engineering, Chemistry & Science NCSU, Box 8301, Raleigh, NC 27695-830.
• October 1990-November 1990: Visiting Professor, Hokkaido University, Department of Biomedical Control, Sapporo 060, Japan.

• Corresponding Member, Latvian Academy of Sciences, 2005
• First Prize of the Latvian Academy of Sciences, 1982
• The Latvian Comsomol Prize, 1974.

• Member of European Tissue Engineering Society
• Member of European Biomechanics Society
• Member of International Community for Composites Engineering

Member of Editorial Boards:

• Editorial Board of the Journal "Biomaterials - Living System Interaction", Moscow, Russia
• Editorial Board of International Journal of Cardiovascular Medicine and Science, USA.

Internal examiner:

• Member of the Promotion Council on Biomechanics, Riga Stradins University, Riga, Latvia (1999 - present)
• Member of the Habilitation and Promotion Council on Engineering Sciences (H-03), Riga Technical University, Riga, Latvia (1992 - present)
• Member of the Specialized Habilitation and Promotion Council (D.081.02.01) on Biomechanics, Latvian Scientific Research Institute of Traumatology and Orthopaedics, Riga, USSR (1989 - 1993).
  

• Hokkaido University, Department of Biomedical Control (Prof. K. Hayashi), Sapporo, Japan, 1990
• Medical University of South Carolina, Department of Cell Biology & Anatomy at the Cardiovascular Development Biology Center (Prof. R. Markward), Charleston, SC, 1998
• North Carolina State University, Department of Textile Engineering, Chemistry and Science (Prof. S. Hudson), Raleigh, NC, 1998
• Clemson University, Department of Bioengineering (Prof. Subrata Saha), Clemson, SC, 1998
• Carolinas Medical Center, Heineman Medical Research Laboratory (Prof. M. J. Thubrikar), Charlotte, NC, 1998
• Florida International University, Cardiovascular Engineering Center (Assoc. Prof. R. Schoephoester), Miami, Fl, 1998
• The Cleveland Clinic Foundation, Department of Biomedical Engineering (Assoc. Prof. I. Vesely), Cleveland, Ohio, 1998
• University of Pittsburgh, Department of Bioengineering (Assoc. Prof. D. Vorp), Pittsburgh, PA, 1999

International grants:

• 2004 – 2005: NATO Grant “Vascular Tissue Engineering by Fusion of Self – Assembling Cell Aggregates”, Co-Investigator (PI – Prof. J. Perez-Pomares).

• 2002 – 2006: SC NASA EPSCor Research Grant Program: “Cardiovascular Tissue Engineering”, Co - Investigator (PI – Prof.R. Markwald, MUSC, Charleston).

• 2002 – 2003 : NIH SBIR Grant „A novel Polymer trileaflet Valve” (PI – Dr. Leonard Pinchuk, Syntheon LLC, Miami, FL, USA).

• 2001 – 2003: Florida/Puerto Rico Affiliate of the American Heart Association grant: „In vitro perfomance characterization of a novel trileaflet synthetic heart valve”, Co-Investigator (PI – Prof. R. Schoephoester, FIU, Miami, USA).

• 2000 – 2002. : National Research Council. Twinning Program 2000 – 2002 With Estonia, Latvia and Lithuania. Mechanical and Hydrodynamic Characterization of a Novel Artificial Trileaflet Aortic Heart Valve Fabricated from Composite Material”, Co-Investigator (PI – Prof. Richard Schoephoester, FIU, Miami, USA)

Latvian grants:

    Principal Investigator:

• 2005 – 2008:  "Tissue engineering of novel vascular graft on the basis of natural and synthetic biodegradable scaffolds”. Grant # 05.1842,  Latvian   Council of Science, Riga, Latvia.
• 2001 – 2004:  “Ingrowths processes and biocompatibility of new artificial vascular graft in organism: morphofunctional and biomechanical investigations”. -    Grant # 01.0721, Latvian  Council of Science. 
• 1997 – 2000: “Investigation of the biomechanical features of human coronary and main brain arteries and development of the novel vascular graft”. -    Grant # 96-0338, Latvian  Council of Science.
  1992 – 1996: “Biomechanics of human blood vessels and development of composite compliant vascular prosthesis”. - Grant # 93.0616,  Latvian  Council of Science.
• 1991: “Biomechanical properties and structure of human arterial vessels”. - Grant # 00802, Latvian  Council of Science
• 1988 – 1990: “Peculiarities of structure and biomechanical behavior of human aortic heart valve and construction of artificial prosthesis”. - Grant # 1008, Ministry of Education of the Latvian SSR, Riga, USSR.
• 1986 – 1987: “Development of novel structures of materials on the basis of investigation of the structure and mechanical behavior of biological tissue and system”. - Grant # 1.10.5.2. Latvian SSR Academy of Sciences, USSR.

    Co-Principal Investigator:

• 2002 – 2005:  “Latvian population senescence and life quality: biomedical and social aspects”.- Joint Project # 02.0012,  Latvian Council of Science
• 2001 – 2004: “New Biomaterial and Medical Technologies”. - Joint Project # 01.0021,  Latvian Council of Science 
• 2001 – 2004: “Functional, Structural and Biomechanical Researches of the Upper Part of the Alimentary Tract in Children and Adults and Usage of the Obtained Outcomes in a Surgical Gastroenterology”.- Grant # 01.0723, Latvian Council of Science
• 2000 – 2003: “Biomechanics of a truncus pulmonalis valve and morphological estimation on the basis of aortic valve exchange using autotransplant”. - Grant # 01.0708, Latvian Council of Science
  
• 1997 - 2000: “Biomaterials and Novel Medical Technology”. - The Latvian National Investigation Program.
• 1980 - 1981: “Durability and strength of polymer materials for artificial human heart valves, blood vessels and organs”. - Grant 10.021,  State Committee on Science and Techniques of the USSR.
  
  Investigator:

• 1997 - 1999: "Biomaterials in Latvia". - European Program "EUREKA-294"
• 1996 - 1998: "Biomechanics of biomaterials in biological systems and computer analysis". - Grant No. 95-1170,  Latvian Council of Science.
• 1991 - 1995: "To develop functional materials on the basis of structure and biomechanical properties of biological tissue". - Grant No. 93.401, Latvian Council of Science
• 1988 - 1990: "To investigate a mechanical behavior of biological tissues and to develop novel structures of composite materials". - Grant No. 1007,  Ministry of Education of the Latvian SSR, Riga, USSR.

Publications: 148, including 65 original papers, one monograph and 13 patents (6 Latvian)

Recent/Representative Publication:

• Kasyanov, V., Purinya, B., Ose, V. Structural and mechanical properties of the human aortic valve. - Mechanics of Composite Materials, 1984, vol.20, N 5, pp.637-647.
• Kasyanov, V., Mungalov, D. A hybrid composite material model for soft biological tissue at high strains. - Mechanics of Composite Materials, 1984, vol. 20, N 6, pp. 751-756.
• Purinya, B., Kasyanov, V., Volkolakov, J., Latsis, R., Tetere, G. Biomechanical and structural properties of the explanted bioprosthetic valve leaflets. - J. Biomechanics, 1994, vol. 27, pp. 1-11.
• Gupta, B., Kasyanov, V. Bio-mechanics of human common carotid artery and design of novel hybrid textile compliant vascular grafts. -  J. Biomedical Materials Research, 1997, vol. 34, pp. 341-349.
• Keris, V., Ozolanta, I., Enina, G., Kasjanov, V., Aide H., Bricis, R. Biomechanical and structural assessment of transluminal angioplasty. -  Medical Engineering and Physics, 1998, vol. 20, pp.339 - 346.
• Ozolanta, I., Tetere, G., Purinya, B., Kasyanov, V. Changes in the mechanical properties, biochemical contents and wall structure of the human coronary arteries with age and sex. - Medical Engineering and Physics, 1998, vol. 20, pp. 525 - 533.
• Kasyanov, V., Ozolanta, I., Purinya, B. Peculiarities of the biomechanical properties of human coronary arteries. Mechanics of Composite Materials, 1999, vol. 2, pp. 221-237.
• Kasyanov V., I. Ozolanta, B. Purinya, V. Mironov. Structure and mechanical properties of the human carotid artery as a biocomposite material. - International Journal of Cardiovascular Medicine and Science, 2000, vol. 3, N 3 / 4, , pp. 127-134.
• Mironov V., Kasyanov V., McAllister K., Oliver S., Sistino J., Markwald R. Perfusion Bioreactor for Vascular Tissue Engineering with Capacities for Longitudinal Stretch. - Journal of Craniofacial Surgery, 2003,vol.14, N 3, pp. 340-347.
• Vanags I., Petersons A., Ose V., Ozolanta I., Kasyanov V., Laizans J., Vjaters E. Biomechanical properties of oesophagus wall under loading. - J. Biomechanics, 2003, vol. 36, N 9, pp. 1387-1390.
• Kasyanov V., I. Ozolanta, B. Purinya, A. Ozols, V. Kancevich. Compliance of a biocomposite vascular tissue in longitudinal and circumferential directions as a basis for creation of artificial substitutes. - Mechanics of Composite Materials, Zinatne, 2003, vol. 39, N 4, pp. 347-358.
• Stradins P., Lacis R., Ozolanta I., Purina B., Ose V., Feldmane L., Kasyanov V. Comparision of biomechanical and structural properties between human aortic and pulmonary valves. - European Journal of Cardio-Thoracic Surgery, 2004, vol. 26, pp. 634-639.
• Kasyanov V., Markwald R., Mironov V. Perfusion Bioreactor for Cardiovascular Tissue Engineering. - In: Book „Bioreactors in Tissue Engineering” (Ed. by Julian Chaudhuri), UK, 2005, p. 285 – 307.
• Mironov V., Kasyanov V., Shu X. Z., Eisenberg C., Eisenberg L., Gonda S., Trusk T., Markwald R. R., Prestwich G., Fabrication of tubular tissue construct by centrifugal casting of cells suspended in an in situ crosslinkable hyaluronan hydrogel. - Biometerials, 2005, vol.26(36), pp. 7628-35
• Kasyanov V., Isenburg J., Draughn R. A., Hazard S., Hodde J., Ozolanta I., Murovska M., Halkes S. B., Vrasidas I., Liskamp R. M. J., Roland J., Pieters R. J., Simionescu D., Markwald R. R., Mironov V. Tannic Acid Mimicking Dendrimers as a Small Intestine Submucosa Stabilizing Nanomordant. - Biomaterials, 2006, vol. 27, N 5, pp. 745-751.
• Mironov V., Kasyanov V., Yost M., Visconti, et al. Cardiovascular Tissue Engineering I. Perfusion Bioreactors: A Review. - J. Long-Term Effects of Medical Implants, 2006, vol. 16, N 2, p. 111-130.
• Gallocher SL., Aguirre AF., Kasyanov V., Pinchuk L., Schoephoerster R.  A novel polymer for potential use in trileaflet heart valve. - J. Biomed. Mater. Res., B Apl. Biomaterial, 2006, vol. 79, N 2, p. 325-334.
• Kasyanov Vladimir, Russell Norris, Brook Damon, Anand Ramamurphy, Thomas Trusk, Gabor Forgacs, Iveta Ozolanta, Janis Vetra, Roger R. Markwald, Vladimir Mironov. Biomechanical properties of a skin of wild and periostin-null mice. In: International Proseeding “MEDIMOND”, The 5th World Congress of Biomechanics, (Ed. By D. Liepsch), Munich, Germany, 29 July - 4 August, Vol. ISBN 88-7587-270-B, 2006, p. 509-516.
• Yanran Liu, Vladimir Kasyanov, Richard T. Schoephoerster. Effect of fiber orientation on the stress distribution within a leaflet of a polymer composite heart valve in the closed position. J Biomechanics, 2007; 40(5), p. 1099-1106.
• Russell Norris, Vladimir Mironov, Brook Damon, Vladimir Kasyanov, Anand Ramamurphy, Ricardo Moreno, Thomas Trusk, Jay Potts , Rich Goodwin, Jeff Davis, Stan Hoffman, Xuejun Wen, Yukiko Sugi, Christine Kern, Gabor Forgacs, Corey Mjaatvedt, Roger R. Markwald. Periostin binding to collagen type I and fibronectin is necessary for proper regulation of collagen fibrillogenesis and maintaining the biomechanical properties of connective tissues. J. Biological Chemistry, 2007, 101(3), p. 695-711.

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Last update 01.10.2007