Ingrida RUMBA-ROZENFELDE

Professor, Dr.habil.med.  Ingrida RUMBA-ROZENFELDE Faculty of Medicine University of Latvia 1a, Sarlotes str. Riga, LV- 1001, Latvia Phone: +371 29217120, +371 67370665 Fax: +371 67366306 E-mail: ingrida.rumba@parks.lv; ingrida.rumba@lu.lv Home address: Vesetas 8-24 Riga LV - 1013, Latvia

Born: September 16, 1959

• Epidemiology of chronic diseases in children , immunogenetics in autoimmune diseases (juvenile arthritis, insulin dependent diabetes mellitus) 
• Viruses in juvenile arthritis
• Medical education research
• Children chronic diseases risk factors, outcomes and damage studies
• Children morbidity, mortality and its structure in Latvia.

My major research fields are paediatric chronic diseases, rheumatology and autoimmune diseases studying epidemiology, genetic markers, viruses in pathogenesis, outcomes and prognostic factors. I am very involved into medical education so I am doing research in this area although. I am  supervisor of 3 research students.

Languages: Latvian, Russian (fluent), English (fluent), German (fluent)

Education:

• Riga Medical Institute, Faculty of Paediatrics, (diploma of physician), 1983
• Riga Medical Institute, Faculty of Paediatrics, postgraduate training in paediatrics, 1983-1985
• Moscow Institute of Rheumatology, PhD student, 1985-1988
• Dr.med. (Candidate of Science in former USSR, PhD in Western countries), institute of Rheumatology, Moscow,1990  
           Thesis “Clinical and genetic investigation of juvenile Rheumatoid arthritis”
• Dr.habil.med., Medical Academy of Latvia, 1996
           Thesis “Epidemiology, immunogenetics and prognosis of Juvenile Chronic Arthritis (JCA)”

• Assistant at Department of Paediatrics, Medical Academy of Latvia (AML), 1988-1992
• Docent at Department of Paediatrics, Medical Academy of Latvia (AML), 1992-1998
• Dean of the Faculty of Paediatrics , AML, 1990-1993
• Vice-Dean of the Faculty of General Medicine, AML, 1993-1997
• Chair of Department of Paediatrics, AML, 1993-1998
• Professor of Paediatrics at the Faculty of Medicine, University of Latvia, 1998 -
• Vice dean, Faculty of Medicine, University of Latvia , 1999 - 2008
• Dean, Faculty of Medicine, University of Latvia , 2008 -
• Head of Paediatric Clinic (2004-2006),  Head of  Adolescent Clinic (2006-2009), Head of Ambulatory (Outpatient) Consultative Clinic (since 2009), Children Hospital Gailezers

Abroad:

• Basel University Paediatric hospital, March- April 1989
• Karolinska Institute, Centre Molecular Medicine,  October 1995
• Karolinska Hospital, Astrid Lindgren Children Hospital, November 1998

• Corresponding Member, Latvian Academy of Sciences, 2005

• Member of Council, Faculty of Medicine
• Chair, Council of Study programme, Faculty of Medicine
• Member, Academic Commission of Natural Sciences, University of Latvia 
• President, Children Rheumatologists Society, Latvia
• Pediatric Society of Latvia (Member of Council, Member of Certification Commission),
• Physician Society of Latvia , Sertification Council, member (until 2002)
• Physician Society of Latvia, Member of Teaching Commission
• Chair of Paediatrics Professors group, Faculty of Medicine, University of Latvia
• Chair of Paediatric Clinic, Faculty of Medicine, University of Latvia
• Member, Scientific Commitee of PRES Congress in Geneva, 2000
• Member, Scientific Commitee of 4th World Latvian Physicians Congress
• Member of Pediatric Commitee, EULAR
• Member, PRES (Pediatric Rheumatology European Society)

• licence of Paediatrician
• licence of Rheumatologist
• licence of Paediatric Rheumatology

• European Paediatric rheumatology annual scientific meeting (member of scientific committee), Geneva, 2000
• 4^th World Latvian Physicians congress (member of scientific committee), Riga, 2001.

Study courses:

• since 1998: pediatrics I, Higher Professional Educational Study Programme in Medicine
• 1998-2002: study course in pediatrics and pediatric rheumatology for general practitioners
• since 2001: study course for general practitioners “Specific health problems of newborns, infants and children”
• since 1998: chair of Study programme Council at Faculty of Medicine, University of Latvia

Created study courses:

• pediatrics, Higher Professional Educational Study Programme in Medicine
• Specific health problems of newborns, infants and children, continuing medical education programme for general practitioners
• Feeding of children and adolescents, Master programme for dieticians

Created study programmes:

• Higher Professional Educational Study Programme in Medicine (accreditation for 6 years)
• Postgraduate educational programme in pediatrics (accreditation for 6 years)
• Project: continuing medical education programme for general practitioners (Latvia health care reorganization) (World Bank foundation, agreement Latvia/Health/B2A#O42/CLC/IBRD) (approved at LU Senate)

• Pediatric Diseases and Their Risk Factors (Bernu slimibu riska faktori) /Ed. and. co-author I. Rumba/, 2009, Riga: LU Akademiskais apgads, 183 pp. (in Latvian)

• Shastry A, Sedimbi SK,  Rajalingam R, Rumba I, Kanungo A, Sanjeevi CB.  Different KIRsconfer suspectibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations - Ann. NY Acad. Sci., 2008 Dec, 1150, pp.133-138.
• Daugule I, Rumba I, Alksnis J.  Helicobacter pylori infection among children with gastrointestinal symptoms: a high prevalence of infection among patients with reflux oesophagitis. - Acta Pediatr., 2007 Jul; 96 (7), p. 1047-1049. Epub 2007 May 24.
• Sedimbi SK, Shastry A, Park Y, Rumba I, Sanjeevi CB.  Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients - Ann. NY Acad. Sci., 2006, 1079, pp. 273-277.
• Daugule I., Rumba I., Ejderhamn J.  Previous antibacterial treatment due to concomitant infections in preschool children is associated with a lower Helicobacter pylori positivity. - Scand. J. Infect. Dis.,  2005; 37(5), pp. 326-9. PMID: 16051567 [PubMed - indexed for MEDLINE]
• Ruperto N, Garcia-Munitis P, Villa L, Pesce M, Aggarwal A, Fasth A, Avcin T, Bae SC, Balogh Z, Li C, De Inocencio J, Dibra M, Dolezalova P, Miedany YE, Flato B, Harjacek M, Huppertz HI, Kanakoudi-Tsakalidou F, Wulffraat N, Lahdenne P, Melo-Gomes JA, Mihaylova D, Nielsen S, Nikishina I, Ozdogan H, Pagava K, Panaviene V, Prieur AM, Romicka AM, Rumba I, Shafaie N, Susic G, Takei S, Uziel Y, Vesely R, Woo P, Martini A. Paediatric Rheumatology International Trials Organisation; Paediatric Rheumatology European Society. PRINTO/PRES international website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it. - Ann Rheum Dis. 2005 Jul;64(7):1101-6. Epub 2005 Mar 10. PMID: 15760930 [PubMed - indexed for MEDLINE]
• Nikitina-Zake L, Rajalingham R, Rumba I, Sanjeevi CB. Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls. - Ann N Y Acad Sci. 2004 Dec;1037:161-9. PMID: 15699512 [PubMed - indexed for MEDLINE]
• Bratslavska O, Rumba I. Human parvovirus B19 and the spectrum of diseases caused by this virus. - Proc. Latvian Academy of Sciences. Section B, 2005, vol. 59,    No.3/4.
• Rumba I, Kozireva S, Ivanova K, Saulite I, Bracslavska O. HHV-6 un parvovirusa B19 infekciju sastopamiba pacientiem ar juvenilo artritu. - Latvijas Universitates raksti, 2005. medicina (15.lpp) (iespiešan Ejderhamn J. Characteristics of Hel icobacter pylori infection among children in Riga. Latvijas Universitates Raksti, 2004., 668.sej. Medicina, 20-28.lpp.
• Daugule I, Rumba I, Engstrand L, Ejderhamn J. Infection with cagA-positive and cagA-negative types of Helicobacter pylori among children and adolescents with gastrointestinal symptoms in Latvia. -  Eur J Clin Microbiol Infect Dis., 2003 Oct; 22(10):622-4. Epub 2003 Sep 24. PMID: 14508659 [PubMed - indexed for MEDLINE]
• Shtauvere-Brameus A, Dabadghao P, Rumba I, Sanjeevi CB. Tumor necrosis factor-alpha allele 2 shows an association with insulin-dependent diabetes mellitus in Latvians.- Ann N Y Acad Sci., 2002 Apr; 958:357-61. PMID: 12021142 [PubMed - indexed for MEDLINE]
• Berzina L, Shtauvere-Brameus A, Rumba I, Sanjeevi CB. Microsatellite allele A5.1 of MHC class I chain-related gene A is associated with latent autoimmune diabetes in adults in Latvia. - Ann N Y Acad Sci., 2002 Apr;958:353-6. PMID: 12021141 [PubMed - indexed for MEDLINE]
• Shtauvere-Brameus A, Ghaderi M, Rumba I, Sanjeevi CB. Microsatellite allele 5 of MHC class I chain-related gene A increases the risk for insulin-dependent diabetes mellitus in latvians. Ann N Y Acad Sci. 2002 Apr;958:349-52. PMID: 12021140 [PubMed - indexed for MEDLINE]
• Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB. Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients. - Ann N Y Acad Sci. 2002 Apr;958:297-304. PMID: 12021128 [PubMed - indexed for MEDLINE]
• Shtauvere-Brameus A, Falorni A, Rumba I, Sanjeevi CB. Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?-  Ann N Y Acad Sci., 2002 Apr; 958:259-62. PMID: 12021119 [PubMed - indexed for MEDLINE]
• Nikitina Zake L, Cimdina I, Rumba I, Dabadghao P, Sanjeevi CB. Major histocompatibility complex class I chain related (MIC) A gene, TNFa microsatellite alleles and TNFB alleles in juvenile idiopathic arthritis patients from Latvia. - Hum Immunol.,2002 May; 63(5): 418-23. PMID: 11975986 [PubMed - indexed for MEDLINE]
• Sjakste N., Sjakste T., Rumba I., Vikmanis U. Proteasomes in pathology. - : Proc.Latvian Acad.Sci., 2002, Section B, Vol.56 , N1/2, pp.7-16.
• Daugule I, Rumba I, Lindkvist P, Bergstrom M, Ejderhamn J.A relatively low prevalence of Helicobacter pylori infection in a healthy paediatric population in Riga, Latvia: a cross-sectional study. - Acta Paediatr., 2001 Oct; 90(10): 1199-201. PMID: 11697436 [PubMed - indexed for MEDLINE]
• Rumba I, Ruperto N, Bikis E, Remberga S, Saulite I, Plotkina N, Viksna A, Krauca M, Breca I, Vikmanis U; Paediatric Rheumatology International Trials Organisation. The Latvian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). -  Clin Exp Rheumatol., 2001 Jul-Aug;19(4 Suppl 23):S101-5. PMID: 11510310 [PubMed - indexed for MEDLINE]
• Sanjeevi CB, Miller EN, Dabadghao P, Rumba I, Shtauvere A, Denisova A, Clayton D, Blackwell JM. Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis. - Arthritis Rheum., 2000 Jun;43(6):1397-404. PMID: 10857800 [PubMed - indexed for MEDLINE]
• Rumba I., Denisova A., Sochnev A., Sanjeevi. C.B. HLA II class genes in Latvia patients with juvenile rheumatoid arthritis (JRA). - Tissue Antigens, 1997, 49 (1), pp. 56-60.
• Shtauvere A, Rumba I, Dzivite I, Sanjeevi CB. HLA-DR and -DQ gene polymorphism in Latvian patients with insulin-dependent diabetes mellitus. - Tissue Antigens, 1998 Oct; 52(4): 385-8. PMID: 9820603 [PubMed - indexed for MEDLINE]
• Rumba I. Immunogenetics of juvenile chronic arthritis (JCA). - Proc.Latvian Acad.Sci., 1996, Vol. 50, N. 2, pp. 57-63.
• Rumba I., Denisova A., Scegolevs A., Socnevs A., Santere R. HLA class II genes in a child with a combination of Ehlers-Danlos syndrome subtype II and juvenile psoriatic arthritis: a case study. - Proc.Latvian Acad.Sci., 1996, Vol. 50, N. 2, pp. 78-81.

  Some international conference abstracts:

  • Sedimbi S.K., Shastry A., Park Y., Rumba I., Sanjeevi C.B. Association of SUMO4 M55V polymorfism with autoimmune diabetes in Latvian patients. - Ann. NY Acad.Sci., 2006 Oct; 1079, p. 273-277.
  • Rumba I, Legzdina I, Medne A. Primary osteoporosis profile in Latvian children.-  3^rd International Bone health conference in children. Bone 36, 2005, S1-S102.
  • Rumba I., Sjakste T., Poudziunas I, Sjakste N. Juvenile idiopathic arthritis associations with PSMA 6 gene. - Clinical Experimental Rheumatology, 2005, P-035.
  • Rumba I., Vikmanis U. Implementation of ECTS into a new medical curriculum. - Abstracts AMEE (Association Medical Education in Europe) Congress, 5-8 Sept. 2004, Edinburg, p.4.120, 8k9.
  • Sjakste T., Poudziunas I., Rumba I., Plotkina N., Saulite., Sjakste N. PSMA6 gene polymorphism and juvenile idiopathic polyarthritis. XI ^th European annual Pediatric Rheumatology Congress. 9-12. sept. 2004, Ko?ice, Slovakia. Clinical Experimental Rheumatology, 2004, Vol. 22, Nr. 4, p.536, Nr.155.
  • Ruperto N., Garcia Hunites P., Villa L., Pesco M., Mihaylova D., Harjacek M., Dolezalova P., Nielsen S., El Miedany Y., Lahdenne P., Prieur AM., Pagava K., Huppertz HI., Kanakaudi F., Balogh Z., Garwal A., Uziel Y., Bae S.C., Rumba I., Panaviene V., Kues W., Flato B., Romicka A.M., Melo-Gomes J.A., Al- Mayof S., Susic G., Vesely R., Arcin T., De Inocencio J., Ozdogan H., Woo P., Martini A. The PRINTO/ PRES International website for families of children with rheumatic diseases: www.pediatric-rheumatology.printo.it XI ^th European annual Pediatric Rheumatology Congress. 9-12. sept. 2004, Kosice, Slovakia, Clinical Experimental Rheumatology, 2004, Vol. 22, Nr. 4, p.542, Nr.188.
  • Rumba I., Bikis E., Remberga S., Cipele L., Krauca M., Zalitis E., Lanka I., Children Health care: 10 Years experience in Latvia. - Abstr. Europediatrics 2003, Epub Prague, 19-22 October 2003.
  • I.Rumba, U.Vikmanis. Students evaluation of the undergraduate Curriculum. In: Relevance in Medical Education. Abstracts of Annual Congress AMEE (Association Medical Education in Europe), 31 August- 3^rd Sept.2003, Bern. University of Bern, 2003, p.4.88, Abstr.8E5.
  • Rumba I., Bracslavska O., Kozireva S. Prevalence of viral infections in juvenile arthritis patients. - X European Pediatric Rheumatology Congress, 2-5 Oct., 2003, Stresa, Italy. Clinical Experimental Rheumatology, 2003, Vol.21, N.5, p. 535, No.24.
  • Rumba I. Growth delay in juvenile arthritis (JA). - European Congress of Rheumatology, IX European Pediatric Rheumatology Congress, Stockholm, June 12-15, 2002. - Annals of the Rheumatic Diseases, July 2002, vol.61, suppl.1, p.444 (ABO388).
  • Rumba I.,Vikmanis U. Innovations in the curriculum at the Medical Faculty University of Latvia. Approaches to Better Teaching. - Abstracts of Annual Congress AMEE (Association Medical Education in Europe).29^th August- 1^st September 2002, Lisbon. University of Lisbon, 2002, p.4. 22, abstr.3A9.
  • Daugule I., Rumba I., Ejderhamn J. Association of a previous antibiotic treatment with H. pylori positivity in a children sample investigated by polyclonal and monoclonal H. pylori stool antigen tests. - XV International Workshop Gastrointestinal Pathology and Helicobacter, Athens, 11-14.IX, 2002.,Gut. 5 1 (Supplement 2). 2002 September, A88.
  • Rumba I., Bikis E., Remberga S. Children health care in Latvia.- Abstr. of the 23rd International Congress of Pediatrics, Beijing, 2001, Sept.9-14, N.I 47.
  • Rumba I., Plotkina N., Saulite I., Autoimmune diseases in juvenile arthritis (JCA) patients families. - VIII European Pediatric Rheumatology Congress , Utrecht, 27-30Sept., 2001. Annals of the Rheumatic Diseases, October , 2001, vol.60, Suppl.II, p.50, P191.
  • Daugule I; Ejderhamn J; Rumba I.; Engstrand L. A high prevalence of cagA+ Helicobacter pylori strains and association with histology among symptomatic children in Latvia. - IX International Workshop Gastrointestinal Pathology and Helicobacter, Strasbourg, 13-18 IX September, 2001.Gut. 49(Supplement II), 2001, A80.
  • Daugule I; Ejderhamn J; Rumba I.; Engstrand L. A high percentage of mixed infections with cagA+ and cagA- Helicobacter pylori strains among symptomatic children in Latvia. - IX International Workshop Gastrointestinal Pathology and Helicobacter, Strasbourg, 13-18 IX September, 2001.Gut.,2001, 49(Supplement II). A77.
  • N.Ruperto, Ravelli, Murray, Giannini, Lovell, Tsitsami, Feldman, Silverman, Machado, Garay, Andersson-Gare, De Cunto, Dolezalova, Hashkes, Honkanen, Hupperts, Joos, Kuis, Lilleby, Melo-Gomes,Ozdogan, Prieur, Rumba, Susic, Woo, Martin. International Consensus for core sets of outcome measures for disease activity (DA) and disease damage (DD) assessment. Part I :Juvenille systemic lupus erythematosus (JSLE). - Annals of the Rheumatic Diseases, Oct.2001, Vol.60, Suppl.II, p.ii8. Abstracts of VIII European Pediatric Rheumatology Congress, Utrecht, 27-30 Sept., 2001.
  • Shtauvere A ; Ghaderi M; Rumba I; Sanjeevi C.B. Microsatellite allele A5.1 of MHC class I chain related gene A is associated with slow onset autoimmune diabetes in clinical non-insuline dependent diabetes in Latvia. - 16^th European Immunohistocompatibility Congress, LeCorum- Montpellier, France,2000. Human Immunology 2000., 275.
  • Shtauvere A ; Ghaderi M; Rumba I; Sanjeevi C.B. Microsatellite allele A5.1 of MHC class I chain related gene A is associated with slow onset autoimmune diabetes in clinical non-insuline dependent diabetes in Latvia. - 17^th Immunology of Diabetes Federation Congress, Mexico City, Mexico, 2000.
  • Ruperto, Murray, Bae, Prieur, Balogh, De Inocencio, Darte, Foeldvari, Hashkes, Huemer, Kanakoudi, Kuzmina, Miranda.Ozdogan, Rumba, Vesely, Alpigiani, Bardare, Falcini, Ferrariani, Lepore, Pouchot, Strano, Woo, Landgraf, Zulian, Martini. An international survey in 29 countries on health related quality of life (HRQOL) in juvenile idiopatic arthritis (JIA). Part II. A generic instrumenth: Child health Questionnaire (CHQ). - VII European Pediatric Rheumatology Congress, Geneva, 23-27.Sept., 2000. Annals of the Rheumatic Diseases, 2000, Vol.59. No.9 p.726.
  • Remberga S., Rumba I., Bikis. Child Healthcare System in Latvia. - Abstr. Europediatrics 2000, Rome, March 18- 21, 2000, GP-3.
  • Rumba I., Kokina A. Epidemiology of Children Rheumatic Diseases in Latvia: 10 years experience. - XIV EULAR Congress. Glasgow, Scotland.6-11 June, 1999, Annals of the Rheumatic Diseases,1999, p. 320, N1298.
  • Shtauvere A ; Ghaderi M; Rumba I; Sanjeevi C.B. Microsatellite allele 5 of MHC class I chain related gene A(MICRA)increases the risk for type I diabetes mellitus in Latvian population. - 4th International Congress of the Immunology of Diabetes Society, Fiuggi, Italy, 1999. Diabetes Metab.Res. Rev., 1999. (Suppl.1.,) 17:23
  • Rumba I., Santere R., Kokina A., Scegolevs A. Juvenile chronic arthritis prevalence in Latvia. - 27 ^th Skandinavian Congress of Rheumatology, 5-8. Jun, 1998. Rheum., Suppl. 108, 1998, P95.
  • Rumba I. 10 jears follow up of 222 Juvenile Chronic arthritis (JCA) cases in Latvia. - Abstr. 5^th European Conference on Paediatric Rheumatology. Garmisch- Partenkirchen, 1997. 1. p.
  • I.Rumba, A.Denisova, A.Sochnev, C.B.Sanjeevi. HLA-DQA1 un DQB1 alleles and haplotypes in Latvians with juvenile rheumatoid arthritis.-  Human Immunology, 1996,47: 79.p.

Research grants:

National:

• (Head of Project). Viruses in juvenile arthrtitis patients.  Latvian Council of Science: grant Nr.461/01.0251.  
• (Head of Project). Virus associated juvenile arthritis: pathogenesis study. Latvian Council of Science: grant Nr.04.1312.  
• MICA and MICB microsatellites and MICA extracellular polymorphisms in Juvenile arthritis patients.

International:

• EU project: Prospective validation of the juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM) disease activity (DA) and disease damage (DD) core sets of outcome measure (QLG1-CT-2000-00514)
• EU project: European information network on paediatric rheumatic diseases (QLG1-CT-2000-00514)
• SOCRATES ERASMUS: Mednet (Medical Education and Didactics Network) (213869-CP-1-2002-1-IT-ERASMUS-TN)
• EU Leonardo da Vinci project CLEAR: Survey „Education system for medical doctors and existing postgraduate courses in Latvia“
• KIRT: (Karolinska Institute Reserch and Training Commitee) (Stockholm) and Latvia joint PhD project coordinator
• KIRT project: Studies on Autoimmune Diabetes in Latvians and other Populations
• KIRT project: Helicobacter pylori infection among children in Riga, Latvia
• PRINTO (Paediatric Rheumatology International Trial Organization) project: Cross-cultural adaptation and validation the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)
• PRINTO project: A randomised trial of 6 months verus 12 montns withdrawal of methotrexate (MTX) in patients with juvenile idiopatnic arthritis (JIA) in clinical remission.
• PRINTO project: Juvenile dermatomyosits (JDM): 5-year phase II single-blind, randomized clinical trial in children with newlydiagnosed JDM: prednisone (PDN) versus PDN plus methotrexate (MTX) versus PDN plus Cyclosporine A. Juvenile systemic lupus erythematosus (JSLE): 5 year phase II single-blind, randomized clinical trial in children with newly diagnosed, WHO class III and IV JSLE proliferative nephritis: PDN and oral cyclophosphamide (CYC) versus high dose intravenous (iv) CYC) versus intermediate dose iv CYC, followed by maintenance with azathioprine.
• EMA (European Medical association) project: EPOWEB (European Post graduate on the WEB)
• Project: Continuing education of general practitioners (Latvia health care reorganization) (World Bank foundation, agreement Latvia/Health/B2A#O42/CLC/IBRD)
• Clinical trial “Efficacy and tolerability of different dosages Mildronate syrup in children” (GRM_97-03), expert