Grigory VEINBERG

Dr. Grigory VEINBERG Dr.habil. chem. Leading Researcher Latvian Institute of Organic Synthesis Aizkraukles iela 21 Riga, LV1006 Latvia Phone: +371 67555946 Fax: +371 67550338 E-mail: veinberg@osi.lv

 

 

Interests:

• Bioorganic Chemistry
• Penicillins and Cephalosporins
• ß-Lactamase and Elastase Inhibitors, Citotoxic Agents
• Quantitative Structure Activity Relationship

Research interests include Quantitative Structure Activity Relationship determination for penicillin and cephalosporin derivatives with Elastase or ß-Lactamase inhibitory properties and nitric oxide generating properties.

Languages: English, Latvian, Russian.

Education:

• Riga Politechnical Institute (Faculty of Chemistry), 1964
• Dr. chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Latvian Academy of Sciences, 1971
• Dr. habil. chem. (Doctor of Science in former USSR), Latvian Academy of Sciences, 1987.

Experience:

Latvian Institute of Organic Synthesis -

• Junior Researcher, 1970-1974
• Senior Researcher, 1975-1983
• Leading Researcher, 1984-

Honours and Awards:

• Corresponding Member, Latvian Academy of Sciences, 2000
• The Latvian Academy of Sciences G.Vanags   Prize, 2009
• The D.H.Grindel Medal (Company "Grindex", Latvia), 2000
• The S.Hiller Medal (Latvian Institute of Organic Synthesis), 1996
• The Latvian Academy of Sciences Presidium Third Award, 1985
• The Latvian Academy of Sciences Presidium First Award, 1974

Professional Activities and Memberships:

• Member, Latvian Council of Science Expert Committee for Chemistry, 1993-
• Member of the Scientific Council,  Latvian Institute of Organic Synthesis, 1999-
• Head of the Scientific Council,  Latvian Institute of Organic Synthesis, 2005 -

Courses:

• Structure Activity Relationships for Organic Substances, Riga Technical University, 1989-
• ß- Lactam Antibiotics, Riga Technical University, 1989-

Recent/Representative Publications:

• G. Veinberg, I. Shestakova, L. Petrulanis, N. Grigan, D. Musel, D. Zeile, I. Kanepe, I. Domrachova, I. Kalvinsh, A. Strakovs, E. Lukevics. Synthesis and Evaluation of Dual Action Cephalosporins as Elastase Inhibitors. - Bioorganic & Medical Chemistry Letters, 1997, vol. 26, N 7, 843.
• G.Veinberg, I.Shestakova, N.Grigan, D.Musel, I.Kanepe, I.Domrachova, I.Grigoryeva, O.Zharkova, I.Turovskis, I.Kalvinsh, A.Strakovs, E.Lukevics. New biological properties of tert-butyl cepalosporanate sulfones. - Eur. J. Med. Chem., 1998, vol. 33, N 10, pp. 755-762.
• G.A.Veinberg, R.Bokaldere, K.Dikovskaya, M.Vorona, D.Musel, H.Kazhoka, I.Turovsky, I.Shestakova, I.Kanepe, I.Domracheva, E.Lukevics. Synthesis of penicillin derivatives and study of their cytotoxic properties. - Khim. Geterotsikl. Soedin., 1998, N 11, pp. 1494-1503.
• P.S.Nys, V.B.Kurochkina, A.V.Skliarenko, G.A.Veinberg. b-Lactams. Structure and biological activity relationship. - Antibiot. Khimioter., 2000, vol. 45, N 11, pp. 36-42 (in Russian).
• G. Veinberg , M. Vorona, I. Shestakova, I. Kanepe, E. Lukevics. Design of b-lactams with mechanism based nonantibacterial activities. - Cur. Med. Chem., 2003, vol. 10, 1741-1757.
• G. Veinberg, R. Bokaldere, M. Vorona, I. Kanepe, I. Shestakova, E. Lukevics.
  The synthesis of cytotoxic 1,3,4-trisubstituted azetidinones-2. - Chem. Heterocycl. Chem., 2003, N 5, pp. 680-687.
• G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, I.Domrachova, E. Lukevics.  Doxorubicin prodrug on the base of tert-butyl cephalosporanate sulfones. -  Bioorg. Med. Chem. Letters, 2004, vol. 14, No 1, 147-150.
• G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, E. Lukevics.  Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones. -   Bioorg. Med. Chem. Letters, 2004, vol. 14, No 4, 1007-1010.
• J.Melnik, M.Vorona, G.Veinberg, J.Popelis, L.Ignatovich, E.Lukevics. The synthesis and stereoisomerism of 2-(1-alkoxyimino-2,2,2-trifluoroethyl)-5-trimethylsilylfurans. - Chem. Heterocycl. Comp., 2005, N 6, pp.834-838.
• M.Vorona, G.Veinberg, I.Shestakova, et al. Synthesis and anticancer properties of 7alpha-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters.  - Chem.Heterocycl. Comp. (Engl. Ed.). 2007, vol. 43, N 2, pp. 207-219.
• M.Dambrova, L.Zvejniece, E.Liepinsh, H.Cirule, O.Zharkova, G.Veinberg, I.Kalvinsh. Comparative pharmacological activity of optical isomers of phenibut. - Eur. J. Pharm., 2008, vol. 583, pp. 128-134.
• M.Vorona, I.Potorochina, G.Veinberg, I.Shestakova, I.Kanepe,  E. Lukevics. Synthesis and stereoisomerism of derivatives of tert-butyl 7-alkylideneceph-3-em-4-carboxylate. - Chem.Heterocycl. Comp. (Engl. Ed.). 2008, vol. 44, N 4, pp.486-493.   
• I.Potorochina, M.Vorona, G.Veinberg, I.Shestakova, I.Kanepe, M.Petrova, E.Liepinsh, E. Lukevics. Synthesis and cytotoxic activity of derivatives of the tert-Butyl ester of 7Z-acethylmethylene-3-methyl-3-cephem-4-carboxylic acid.  - Chem.Heterocycl. Comp. (Engl. Ed.). 2009, vol. 45, N 2, pp. 228-244.  

 

Research Projects:

• G.A.Veinbergs (Head of Project). Beta Lactam Containing Antibiotics. Latvian Council of Science (1991-1993).
• G.A.Veinbergs (Head of Project). Investigation of Cephalosporin Analogs. Latvian Council of Science (1994-1996).
• G.A.Veinbergs (Head of Project). Cancer Factors in the Genesis of Tumor Metastasizing and Its Pharmacological Control. Latvian Council of Science (1995-1996).
• G.A.Veinbergs (Head of Project). Dual Action Anti-inflammatory Cephalosporis. Latvian Taiho Fund (1994 -1996).
• G.A.Veinbergs (Head of Project). The Synthesis of Anti-inflammatory and Citotoxic Cephalosporin Analogs. Latvian Council of Science (1997-2000).
• G.A.Veinbergs (Head of Project). The Synthesis of NO Generating ß-Lactam Antibiotics Analogs. Latvian Council of Science (1997-2000).
• G.A.Veinbergs (Head of Project). Cancer Factors in the Genesis of Tumor Metastasing and Its Pharmacological Control. Latvian Council of Science (1997- 2000) .
• G.A.Veinbergs (Head of Project). The   Synthesis and Biological Investigation of  ß-Lactam Derivatives Acting as Protease Inhibitors.  Latvian Council of Science ( 2001 - 2004) .
• G.A.Veinbergs (Head of Project). The Synthesis of   NO Generating  ß-Lactam Antibiotics Analogs. Latvian Council of Science ( 2002 - 2005) .
• >G.A.Veinbergs (Head of Project). Generation of biochemically induced cytotoxic signal photon emission in monolayer cells.  Latvian Council of Science ( 2005 -  ) .
• G.A.Veinbergs (Head of Project). Synthesis and biological investigation of anticancer beta-lactam derivatives.   Latvian Council of Science (2005 -  ) .

Last update 08.11.2009