Liepins.JPG (8200 bytes) Edvards Liepins, Dr.habil.chem.
Latvian Institute of Organic Synthesis
Aizkraukles iela 21
Riga, LV 1006

Phone: +371 67555985
Fax:  +371 67550338
e-mail: edv@osi.lv

Born: July 1, 1944, Tukums, Latvia


Languages: Latvian, Russian, English.



Honours and Awards

Professional Activities

Recent/Representative Publications

More than 500 full papers, theses at conferences, author sertificates and patents.

  1. G.Otting, E. Liepinsh, K.Wuthrich. Protein hydration in aqueous solution. - Science, 1991, vol. 254, pp. 974-980.
  2. E.Liepinsh, K.D.Berndt, R.Sillard, V.Mutt, G.Otting. Solution structure and dynamics of PEC-60, a protein of Kazal type inhibitor family, determined by nuclear magnetic resonance spectroscopy. - Journal Molecular Biology, 1994, vol. 239, pp. 137-153.
  3. E Liepinsh., G.Otting. Specificity of urea binding to proteins. - Journal of American Chemical Society, 1994, vol. 116, pp. 9670-9674.
  4. G.Otting., E.Liepinsh. Protein hydration viewed by NMR spectroscopy. - Accounts of Chemical Research, 1995, vol. 28, pp. 171-177.
  5. E.Liepinsh, G.Otting. Proton exchange rates from amino acid side chains - implications for image contrast. - Magnetic Resonance in Medicine, 1996, vol. 35, pp. 30-42.
  6. E.Liepinsh, G.Otting. Organic solvents identify ligand binding sites on protein surfaces. - Nature Biotechnology, 1997, vol. 15, pp. 264-268.
  7. G.Otting, E.Liepinsh, B.Halle, U.Frey. Hydrophobic cavities with low water occupancies in protein structures: NMR identification by use of small gas molecules. - Nature Structural Biology, 1997, vol. 4, pp. 396-404.
  8. E.Liepinsh, M.Andersson, J.-M.Ruyschaert, G.Otting. Saposin fold revealed by the NMR structure of NK-lysin. - Nature Structural Biology,1997, vol. 4, pp. 793-795.
  9. E.Liepinsh, M.Kitamura, T.Murakami, T.Nakaya, G.Otting. Pathway of chymotrypsin evolution suggested by the structure of the FMN-binding protein from Desulfovibrio vulgaris (Miyazaki F). - Nature Structural Biology, 1997, vol. 4, pp. 974-979.
  10. E.Liepinsh, L.L.Illag, G.Otting, C.F.Ibanez. NMR structure of the death domain of the p75 neurotrophin receptor. - The Embo Journal ,1997, vol. 16, pp. 4999-5005.
  11. E.Liepinsh, M.Kitamura, T.Murakami, T.Nakaya, G.Otting. Common ancestor of serine proteases and flavin-binding domains. - Nature Structural Biology, 1998, vol. 5, pp. 102-103.
  12. E. Liepinsh, P. Sodano, S. Tassin, D. Marion, F. Vovelle, G. Otting. Solvation study of the non-specific lipid transfer protein from wheat by intermolecular NOEs with water and small organic molecules . -
    J. Biomol. NMR , 1999, vol. 15, pp. 213-225.
  13. L. L. Ilag, C. Rottenberger, E. Liepinsh, G. Wellnhofer, F. Rudert, G. Otting, L. L. Ilag. Selection of a peptide ligand to the p75 neurotrophin receptor death domain and determination of its binding site by NMR. - Biochem. Biophys. Res. Commun., 1999, vol. 255, pp. 104-109.
  14. Y. Yang, W. J. Griffiths, M. Nordling, J. Nygren, L. Möller, J. Bergman, E. Liepinsh, G. Otting, J.-A. Gustafsson, J. Rafter, J. Sjövall Ring opening of benzo[a]pyrene in the germfree rat is a novel pathway for formation of potentially genotoxic metabolites. - Biochemistry, 2000, vol. 39, pp. 15585-15591.
  15. E. Liepinsh, M. Baryshev, A. Sharipo, M. Ingelman-Sundberg, G.Otting, S. Mkrtchian .
    Thioredoxin-fold as a homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa homodimer. -  Structure, 2001, vol. 9, pp. 457-471
  16. E. Liepinsh, M. Trexler, A. Kaikkonen, J. Weigelt, L. Banyai, L.Patthy, G. Otting. NMR structure of the LCCL domain and implications for DFNA9 deafness disorder. - EMBO J., 2001, vol. 20, pp. 5347-5353.
  17. N. K. Williams, P. Prosselkov, E. Liepinsh, I. Line, A. Sharipo, D. R. Littler, P. M. G. Curmi, G. Otting, N. E. Dixon.
    In vivo protein cyclization promoted by a circularly-permuted Synechocystis sp. PCC6803 DnaB mini-intein. - 
    J. Biol. Chem. , 2002, vol. 277, pp. 7790-7798.
  18. E. Liepinsh, G. Otting, M. M. Harding, L. G. Ward, J. P. Mackay, A. D. J. Haymet .Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein. - Eur. J. Biochem., 2002, vol. 269, pp. 1259-1266.
  19. Liepinsh E. Banyai L. Pintacuda G. Trexler M. Patthy L. Otting G. NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding. - Journal of Biological Chemistry, 2003, vol.  278, N 28, pp. 25982-25989
  20. Liepinsh E. Leonchiks A. Sharipo A. Guignard L. Otting G. Solution structure of the R3H domain from human S mu bp-2. - Journal of Molecular Biology, 2003, vol. 326, N 1, pp. 217-223..
  21. Liepinsh E. Genereux C. Dehareng D. Joris B. Otting G. NMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains. - Journal of Molecular Biology, 2003, vol. 327, N 4, pp. 833-842.
  22. Liepinsh E., Barbals R., Dahl E., Sharipo A., Staub E., Otting G. The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. - Journal of Molecular Biology,. 2003, vol. 332, N 5, pp. 1155-1163.
  23. Modig K., Liepinsh E., Otting G.,  Halle B. Dynamics of protein and peptide hydration. - J. Am.   Chem. Soc., 2004, vol.126, N 1, pp.102-114.
  24. Liepinsh E., Rakonjac M., ;Boissonneault V., Provost P., Samuelsson B., Radmark O., Otting G. NMR structure of human coactosin-like protein. - Journal of Biomolecular NMR , 2004, vol.30, N 12, pp. 353-356.
  25. Mutulis F., Yahorava S.; Mutule I., Yahorau  A., Liepinsh  E., Kopantschuk   S., Veiksina  S., Tars K., Belyakov  S., Mishnev  A., Rinken   A., Wikberg  J.E.S. New substituted piperazines as ligands for melanocortine receptors. Correlations to the X-ray structure of “THIQ”. - Journal of Medicinal Chemistry, 2004, vol. 47, pp. 4613-4626.
  26. Norberg  A., Hoa N.K., Liepinsh  E., Phan  D.O., Thuan N.D., Jornvall H., Sillard R., Osteson C.-G. A. novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. - Journal of Biological Chemistry, 2004, vol. 279, N 40, pp. 41361- 41367.
  27. Hosia W., Bark N., Liepinsh E., Tjernberg A., Persson B., Hallen D., Thyberg  J., Johansson J., Tjernberg L. Folding into a ?-hairpin can prevent amyloid fibril formation. - Biochemistry, 2004, vol. 43, N 16, pp. 4655-4661.
  28. Liepinsh E., Banyai L., Patthy L., Otting G. NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. - J.Mol.Biol., 2006, vol. 357, N 3, pp. 942-950.
  29. Li J., Liepinsh E., Almlen A., Thyberg J, et al. Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C. - FEBS Journal, 2006, vol. 273, N 5, pp. 926-935.
  30. Liepinsh E., Nagy A., Trexler M., Patthy L., Otting G. Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein. - J.Biomolecular NMR, 2006, vol. 35, N 1, pp. 73-78.

Resarch Projects

Last update 26.09.2007