Modra MUROVSKA
Born: July 16, 1949, Saldus, Latvia
Interests:
- Virology, oncovirology, human retroviruses and regulation
of their replication
- Virus and cell interaction, transforming ability of
HTLV-BLV group retroviruses, their role in pathology, methods of diagnostics and
prophylactics, antisense polynucleotides as inhibitors of virus replication
- Blood-borne viruses (human herpesviruses – CMV,
HHV-6, -7, -8, human parvovirus B19), activation of latent/persistent virus infections
against immunosuppression background
- Implication of viruses in the pathogenesis of autoimmune
diseases
- Hematological malignancies
Languages: Latvian, Russian, English - fluent, German - read
and translate.
Education
MD, Riga Medical Institute /Medical Academy of Latvia/ (Faculty of Pediatrics), 1972
Dr.med. (Candidate of Science in former USSR system, Ph.D. in Western countries), Cancer
Research Centre, USSR Academy of Medical Sciences, Moscow, Russia,1978
Experience
August Kirchenstein Institute of Microbiology and
Virology:
- Acting Director, 2006 -
- Head of the Laboratory of Oncovirology, 1986-
- Senior Researcher, 1981-1986
- Junior Researcher, 1974-1981
- Postgraduate, 1973-1976
- Senior laboratory assistant, 1972-1973
Studies abroad and professional qualification:-
Certificate of the Association of Latvian
physicians in Medical microbiology (1995-2005, 2005-2010)
Guest Researcher, Department of Haematology, University
of Cambridge, 2001
Guest Researcher, Department of Medical Sciences, Uppsala
University (Scholarship of the Swedish Institute), 1998
Training: HTLV Phylogenetic Analysis, Katholieke
Universiteit Leuven, Belgium, 1996
Nordic Medical Council fellowship holder, Department of
Virology, the National Veterinary Institute, Uppsala, Sweden, 1993-1994
Japanese Society for the Promotion of Science fellowship
holder, Kochi Medical School, National Cancer Centre Research Institute, Institute of
Atomic Diseases of Nagasaki University Medical School, Japan, 1986-1987; 1989-1990.
Honours and Awards
Corresponding Member, Latvian Academy of Sciences, 2004
American Society for Microbiology Morrison Rogosa Award, 2000
The Latvian Academy of Sciences Presidium First Award, 1986
The Latvian Academy of Sciences Presidium Second Award, 1978
Professional Activities and Memberships
Association of Latvian Scientists
Latvian Association of Medical Microbiologists
Latvian Association of Haematologists
American Society for Microbiology
International Association for Chronic Fatigue Syndrome (IACFS/ME)
European Association for Cancer Research
European Society for Veterinary Virology
International Retrovirology Association HTLV and Related
Viruses
Member, Latvian Council of Science Experts’
Committee for Molecular Biology, Biotechnology, Microbiology and Virology, 1993 –
2003
Member, Latvian Council of Science Experts’
Committee for Medicine, 2003-2007
Member, Latvian Council of Sciences Joint Experts’ Committee for Biology and
Medicine, 2003-2007
Member, Latvian Council of Sciences Experts’ Committee for Biology and Medicine,
2007-
Publications: 264, including 91 original papers, 4 review
papers and one monograph
Recent/Representative Publications
- M.Murovska, S.Lejniece, S.Kozireva. M.Koulikovska, H.Yin, J.Blomberg. Human
retrovirus 5 sequences in peripheral blood cells of patients with B-cell
non-Hodgkin’s lymphoma. - Int. J. Cancer, 2000, vol.85, 762-770.
- S.Chapenko, I.Folkmane, V.Tomsone, D.Amerika, R.Rozentals, M.Murovska.
Co-infection of two b-herpesviruses (CMV and HHV-7) as an increased risk factor for
“CMV disease” in patients undergoing renal transplantation. – Clin.
Transplantation, 2000, vol. 14, N 5, pp. 486-492
- M.Murovska, S.Kozireva, V.Tomsone. Antisense RNA-mediated
inhibition of bovine leukemia virus replication in transgenic rabbits. - Experimental
Oncology, 2001, vol.23, N 1, pp. 51-56.
- S.Chapenko, I.Folkmane, V.Tomsone, S.Kozireva, J.Bicans, D.Amerika,
R.Rozentals, M.Murovska. Infection of ß-herpesviruses
(CMV, HHV-6, HHV-7): Role in postrenal transplantation complications. -Transplantation
Proceedings, 2001, vol.33, N 4, pp. 2463-2464.
- S.Kozireva, S.Lejniece, J.Blomberg, M.Murovska. Human retrovirus
type 5 sequences in non-Hodgkin’s lymphoma of T cell origin. - AIDS Research and
Human Retroviruses, 2001, vol.17, N 10, pp. 953-956.
- V.Tomsone, I.Logina, A.Millers, S.Chapenko, S.Kozireva, M.Murovska.
Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of
the nervous system. - J. Neurovirol., 2001, vol. 7, N 6, pp. 564-569.
- Chapenko S., Millers A., Nora Z., Logina I., Kukaine R., Murovska
M. Correlation between HHV-6 reactivation and multiple sclerosis disease activity. - J.
Med. Virol., 2003, 69(1): 111-117.
- Forsman A., Uzameckis D., Rönnblom L., Backlund E.,
Aleskog A., Bindra A., Pipkorn R., Lejniece S., Kozireva S., Murovska M., Blomberg
J. Single-tube nested quantitative PCR: a rational and sensitive technique for detection
of retroviral DNA. Application to RERV-H/HRV-5, and conformation of its rabbit origin. - J.
Virol. Methods, 2003, 111(1): 1-11.
- Murovska M., Kozireva S., Roce A., Danilane I.,
Mikazane H., Lejnieks A. Implication of HHV-6 in the pathogenesis of rheumatoid arthritis.
- Proc II European Congrss of Virology, Medimond, 2004, pp. 51-54.
- Kasyanov V., Isenburg J., ...., Murovska M.,
Halkes S.B., et al. Tannic acid mimicking dendrimers as small intestine submucosa
stabilizing nanomordants. - Biomaterials, 2006, vol.27, N 5, pp. 745-751.
- Chapenko S., Krumina A., Kozireva S., Nora Z., Sultanova A., Viksna L. Murovska M.
Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J
Clin Virol Suppl., 2006: S47-S51.
- Sultanova A., Capenko S., Nora Z., Donina S., Murovska
M. Imunsupresija ka ß-herpesvirusu aktivacijas
faktors pacientiem, kam ir kunga un zarnu trakta audzejs. Latvijas Universitates
raksti. Medicina, 2007, 712: 20-24.
Guidance of Research Projects
- Immunomodulating viruses, strategy of infection diagnostic and possibilities of therapy
correction”, project of the National Research Program „Investigation of major
pathologies endangering survival and life quality of Latvian inhabitants with the help of
multidisciplinary consortium” (Head of Project). Latvian Council of Science
(2006-2009);
- Persistence of human parvovirus B19 (Head of Project). Latvian Council of Science
(2004-2008);
- Role of persistent infection of ß-herpesviruses in etiopathogenesis of rheumatic and
inflammatory neural diseases (Head of Project). Latvian Council of Science
(2004-2008);
- Involvement of the chemokine receptor genes identified within the human 3p21.3 region,
in haematological malignances (Head of Latvian Part of Project). The Royal Swedish
Academy of Sciences (2004);
- Human retroviruses: structure, properties (HRV-5) and replication control using
antisense approach (HTLV-I). Latvian Council of Science (2001-2003);
- Persisting viral infections and autoimmunity: implication of viruses in the pathogenesis
of autoimmune diseases. Latvian Council of Science (2001-2003);
- Role of Human Herpes Viruses and Human Retroviruses in the Development of Posttransplant
Complications. Swedish Institute in the frame of Visby Programme (2002, 2003);
- Involvement of the Chemokine Receptor Gene Cluster Identified within the Common
Eliminated Region 1 (CER1) on Human 3p21.3, in Haematological Malignancies. Swedish
Institute in the frame of Visby Programme (2001, 2002);
- Blood-borne Virus Infections in Latvia and Sweden. Swedish Institute in the frame of
Visby Programme (1998, 1999, 2000, 2001, 2002, 2003);
- Activation and Interaction of Herpesviruses (HCMV, HHV-6, HHV-7, HHV-8) against an
Immunosuppression Background. Molecular Epidemiology of HTLV-I/-II and Investigation of
Pathogenesis Mechanisms of Related Diseases. Latvian Council of Science (1997-2000);
- HTLV Group Virus/-es/ Spreading in Latvia, its/their/ Characteristics and Role in
Pathology, Methods of Diagnostics and Prophylactics. An Investigation of the Effect of
Antisense RNA Genes on Bovine Leukaemia Virus Reproduction in vitro and in vivo. Latvian
Council of Science (1991-1996);
- 4 Diploma Works and 5 Promotion Works;
- NorFA Course for PhD students of Nordic countries "Biology of Persistent and Latent
Viral Infections in Animals and Man", 1999
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Last update 09.01.2008
