Maija Ruklisha

ruklisa.JPG (7145 bytes) Professor Maija Ruklisha

Senior Researcher
Head of Laboratory of Metabolism Control of Producers
Institute of Microbiology & Biotechnology, University of Latvia
Kronvalda bulv. 4
Riga, LV 1586

Phone: +371 7034866
Fax: +371 7034866




Brief Description of Main Research:

General principles of metabolism and product (lysine, valine) synthesis control in Corynebacterium glutamicum were investigated. The aim of these studies was the development of theoretical principles enabling to maintain high microbial process productivity and comparatively low production cost of amino acids. It was estimated that the essential parameter to increase the productivity of the technological process of amino acid synthesis was the increase of product yield from C-substrates. Metabolite flux control in bacterial cells (the activity of substrate uptake, central metabolic pathway functioning and product export) was established as the most significant method for the increase of product experimental yield from C-substrates (Ruklisha et al., 1992, 1993, 2000, 2001, Paegle & Ruklisha, 2003).
Principles of metabolite flux control depending on the rate of energy generation and utilization in the cells, switching on or off the stringent control mechanism and others were investigated and applied to improve lysine and valine biosynthesis by C. glutamicum cells.

Languages: Latvian, English, Russian




Professional Activities and Memberships: 

Honours and Awards:


Biochemical Responses of Brevibacterium flavum to Substrate Concentrations and Medium Mixing Intensity. Invited lecture, 11th International Congress of Chemical Engineering, Prague, September, 1993.


University of Latvia (Faculty of Biology) -

Recent/ Representative Publications

151  scientific publications (1 monograph, 52 articles in internationally reviewed journals) and 13 patents

Participation in International Congresses and Conferences

    33 European and International congresses and conferences.

* Years 2000-2003:


International Collaboration


Research Projects supported by the Latvian Council of Science:

Research Projects supported by the European Union:

(EF 5 program "Quality of Life", European Commission, contract No.QLK3–C–2000-00497, years 2001– 2003)

Other Research Projects (Agreements):

Participation in License Affairs

On “Lysine producing strains and technologies” (With Hungary, 1995, Yugoslavia, 1998; Finland, 1993) 

Last update 12.09.2007