Latvian Academy of Sciences

Latvian CHEMISTS (Medicinal Chemistry)

© Latvian Academy of Sciences, 2000

Last updated: April, 2004

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Edgars ABELE, Dr.habil.chem.

• K.Rubina, E.Abele,  P.Arsenyan, R.Abele, M.Veveris, E.Lukevics.   Synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents. - Metal-Based Drugs, 2001, vol. 8, N 2, pp. 85-93. 

Born: 1962, Riga, Latvia

Phone: +371 7551822.  Fax: +371 7550338
E-mail: abele@osi.lv

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• Chemistry, Medicinal

 

• E.Alksnis, D.Korneeva, E.Lukevics.  Adenine and uracil derivatives with antitubercular activity. - Chem. Heterocycl. Comp., 2001,  vol. 37, N 1, pp. 743-746. 

Born: 1959, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 9410721.  Fax: +371 7242074
E-mail: latvis@apollo.lv

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Janina BRIEDE, Dr.biol.

Main interests:

• Chemistry, Medicinal

-pharmacology,
-endocrinology,
-cardiovasculary and neurophysiology

• J. Briede, K.Heidemanis, I.Dabina, G. Duburs. Effect of Cerebrocrast on the function of the humanplatelets and release of arachidonic acid from plasmatic membranes. - Cell Biochem., 2001, Vol. 19, pp. 1-5. 

Born: 1937, Daugavpils district, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: janina@osi.lv

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Main interests:

• Chemistry, Medicinal

• J.Briede, D.Daija, E.Bisenieks, N.Makarova, J.Uldrikis, J.Poikans, G.Duburs. Effects of some 1,4-dihydropyridine Ca antagonists on the blast transformation of rat spleen lymphocytes. - Cell Biochem. Funct., 1999, vol. 17, pp. 97–105.

Born: 1942, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: daina@osi.lv

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Main interests:

• Medicinal chemistry
• Pharmaceutical pharmacology

• M.Dambrova, L.Baumane, A.Kiuru, I.Kalvinsh, J.E.S.Wikberg. N-Hydroxyguanidine compound 1-(3,4-dimethoxy-2-chlorobenzylideneamino)-3-hydroxyguanidine inhibits the xanthine oxidase mediated generation of superoxide radical. - Arch. Biochem. Biophys., 2000, Vol. 377, N 1, pp. 101-108.

Born: 1968, Gulbene, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7702115 Fax: +371 7550338
E-mail: dambrova@biomed.lu.lv

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• Chemistry, Organic & Medicinal

- heterocyclic compounds
- medicinal chemistry

Recent/Representative Publication

• A. Krauze, V.Garaliene, R.Vitolina, G.Duburs. Synthesis of 4,5-dipirydin-2(1H)-ones, pyridine-2-(1H)-thiones and related derivatives as analogues of cardiotonic drug milrinone.- Heterocycl. Commun., 2001, Vol. 7, N 5, pp. 427-432.  

Born: 1934, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006. Latvia

Phone: +371 7551232. Fax: +371 7550338
E-mail: gduburs@osi.lv

Home page: click here

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Main interests:

• Chemistry, Organic & Medicinal

- nitrogen containing heterocycles
- synthesis of substances with antiviral and analgetic activity

• J.Sulojeva, M.Jure, E.Gudriniece, A.Gutsait, M.Petrova. Synthesis of 2,3-dihydroimidazo[1,2-a]pyridines on the basis of 1,3-diketones. - Khim. Geterotsikl. Soed., 2001, N 7, pp. 947-951. 

Born: 1961, Jelgava district, Latvia

Riga Technical University, Faculty of Materials Science and Applied Chemistry
Azenes iela 14, Riga, LV 1048, Latvia

Phone: +371 7089220. Fax: +371 7616765
E-mail: mara@ktf.rtu.lv

Home page: click here

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Main interests:

• Chemistry, Organic & Medicinal

• A.Lorenzen, C.Stannek, H.Lang, V.Andrianov, I.Kalvinsh, U.Schwabe. The sCharacterization of a G protein-coupled receptor for nicotinic acid. - Mol. Pharmcol., 2001, Vol. 59, N 2, pp 349-357. 

Born: 1947, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006,Latvia

Phone: +371 7 553233. Fax: +371 7541644
E-mail: kalvins@osi.lv

Home page: click here

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Main interests:

• Chemistry, Organic & Medicinal

- modern organic synthesis
- adamantane chemistry
- synthesis of potential NMDA receptor anatagonists

Recent/Representative Publication

• A.Jirgensons, V.Kauss, I.Kalvinsh, M.R.Gold, W.Danysz, C.G.Parsons, G.Quack. Synthesis and structure-affinity relationships of 1,3,5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site. - Eur.J.Med.Chem., 2000, Vol. 35, pp. 1-11.  

Born: 1954, Aluksne district, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7828114
E-mail: valerjan@osi.lv 

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Main interests:

• Chemistry, Organic & Medicinal

- unnatural amino acids
- synthesis of antihypertensive compounds

Recent/Representative Publication

• V.A.Slavinskaya, Dz.E. Sile, N.G.Panchenko, E.Kh. Korchagova, G.F.Rozental, Yu.Yu. Balodis, I.V. Turovskis, S.Kh.Grinberga, E.Lukevics. Hydrogenation of derivatives of 2-oxo-4-(2-thienyl)butenoic acid at palladium and nickel catalysts, - Chem. Heterocycl. Comp. (Engl. Ed.), 1998, vol.34, N 10, pp.1127-1131.

Born: 1943, Tatary, Russia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: elmira@osi.lv

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Main interests:

• Chemistry, Organic & Medicinal

Recent/Representative Publication

• A. Krauze, V.Garaliene, R.Vitolina, G.Duburs. Synthesis of 4,5-dipirydin-2(1H)-ones, pyridine-2-(1H)-thiones and related derivatives as analogues of cardiotonic drug milrinone.- Heterocycl. Commun., 2001, Vol. 7, N 5, pp. 427-432.  

Born: 1952, Omsk , Russia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: krauze@osi.lv

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Main interests:

• Chemistry, Organic & Medicinal

Recent/Representative Publication

• E.Lukevics, P.Arsenyan, I.Shestakova, I.Domracheva, A.Nesterova, O.Pudova. Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles. - Eur. J. Med. Chem., 2001, Vol. 36, N 6, pp. 507-515. 

Born: 1936, Liepaja, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: lukevics@osi.lv

Home page: click here

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Main interests:

• Chemistry, Medicinal& Organic

- drug design
- synthesis of heterocyclic compounds

Recent/Representative Publication

• J.Briede, D.Daija, E.Bisenieks, N.Makarova , J.Uldrikis, J.Poikans, G. Duburs. Effects of some 1,4-dihydropyridine Ca antagonists on the blast transformation of rat spleen lymphocytes. - Cell Biochem. Funct., 1999, vol. 17, pp. 97–105. .

Born: 1956, Kaliningrad, Russia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: aiva@osi.lv

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Main interests:

• Chemistry, Medicinal

• N.Sjakste , L.Baumane, D.Meirena, L.Lauberte, M.Dzintare, I.Kalvinš. Drastic increase in nitric oxide content in rat brain under halothane anaesthesia revealed by EPR method. - Biochem. Pharmacol., 1999, vol. 58, N 12, pp.1955–1959.

Born: 1941, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: sjakste@osi.lv

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Main interests:

• Chemistry, Medicinal&Organic

• H.B.Schiöth, P.Prusis, R.Muceniece, F.Mutulis, I.Mutule, J.E.S.Wikberg. Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor. - Peptides, 1999, vol. 20, pp. 395– 400.

Born: 1945, Kraslava, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: fmutulis@osi.lv
Felikss.Mutulis@farmbio.uu.se

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Main interests:

• Chemistry, Medicinal&Organic

- bioorganic chemistry

Recent/Representative Publication

• L.Polevaya, T.Mavromoustakos, P.Zoumboulakis, et al. Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of ?*- ?* interactions in the C-terminal  aromatic residue for antagonist activity and its structure resemblance with AT(I) non-peptide antagonists. - Bioorg. Med. Chem., 2001, vol. 9 (6), pp. 1639-1647.

Born: 1941, Russia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: polevaya@osi.lv

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• Chemistry, Medicinal

- analytics of pharmaceutical preparations

• Quality management in analytical laboratory

• O.Pugovics, V.Kauss, I.Kalvinsh, M.R.Gold. The synthesis of (3.5-di-tert-butyl-4-hydroxyphenyl)methyl- -(3-pyridylalkyl)ethers via 1-(3,5-di-tert-butyl-4-hydroxyphenyl) methyl pyridinium salts. - Syth. Commun., 1998, N 12, vol. 28, pp.2227-2236.

Born: 1963, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: osvalds@osi.lv

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Main interests:

• Chemistry, Medicinal

-peptide chemistry and analysis

• I.Bobrova, N.Abissova, N.Mishlakova, G.Rozentals, G.Chipens. Sythesis and biological activity of branched enkephalin analogues, Eur. J. Med. Chem., 1998, vol. 33, N 4, pp.255-266.

Born: 1941, Liepaja, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: guntis@osi.lv

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Main interests:

• Chemistry, Medicinal

• E.Lukevics, P.Arsenyan, I.Shestakova, I.Domracheva, A.Nesterova, O.Pudova. Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles. - Eur. J. Med. Chem., 2001, Vol. 36, N 6, pp. 507-515. 

Born: 1948, Potsdam, Germany

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7702115. Fax: +371 7550338
E-mail: irina@osi.lv

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Main interests:

• Chemistry, Medicinal

- synthesis of antihypertensine compounds

Recent/Representative Publication

• V.A.Slavinskaya, Dz.E. Sile, N.G.Panchenko, E.Kh. Korchagova, G.F.Rozental, Yu.Yu. Balodis, I.V. Turovskis, S.Kh.Grinberga, E.Lukevics. Hydrogenation of derivatives of 2-oxo-4-(2-thienyl)butenoic acid at palladium and nickel catalysts. - Chem. Heterocycl. Comp. (Engl. Ed.), 1998, vol.34, N 10, pp.1127-1131.

Born: 1946, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: elmira@osi.lv

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Main interests:

• Chemistry, Medicinal

• N.Sjakste , T.Sjakste. Transcription factors and the nuclear matrix: Review. - Mol. Biology, 2001, Vol. 35, N 5, pp. 627-635

Born: 1955, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: sjakste@osi.lv

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Jelena SULOJEVA, Dr. chem.

Main interests:

• Chemistry, Organic & Medicinal

- nitrogen containing heterocycles
- synthesis of substances with antiviral and analgetic activity

• J.Sulojeva, M.Jure, E.Gudriniece, A.Gutsait, M.Petrova. Synthesis of 2,3-dihydroimidazo[1,2-a]pyridines on the basis of 1,3-diketones. - Khim. Geterotsikl. Soed., 2001, N 7, pp. 947-951. 

Born: 1961, Jelgava district, Latvia

Riga Technical University, Faculty of Materials Science and Applied Chemistry
Azenes iela 14, Riga, LV 1048, Latvia

Phone: +371 7089220. Fax: +371 7616765
E-mail: mara@ktf.rtu.lv 

Gunars TIRZITIS, Dr.chem.

• Chemistry, Medicinal

• G.Tirzitis, D.Tirzite, Z.Hyvonen. Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl- -1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation. - Czech J.Food Sci., 2001, Vol. 19, N 3, pp. 81-84.

Born: 1935, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551335.  Fax: +371 7550338
E-mail: tirzitis@osi.lv

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Dace TIRZITE, Dr.biol.

Main interests:

• Chemistry, Medicinal

• G.Tirzitis, D.Tirzite, Z.Hyvonen. Antioxidant activity of   2,6-dimethyl-3,5-dialkoxycarbonyl- -1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation. - Czech J.Food Sci., 2001, Vol. 19, N 3, pp. 81-84.

Born: 1953, Madona, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822 Fax: +371 7550338
E-mail: dace@osi.lv

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Main interests:

• Chemistry, Medicinal & Organic

- gel-forming small molecules; use of aqueous gels in antigen presentation
- melanoma cell permeant peptides as drug carriers
- synthesis of fluorescent peptides
- synthesis of boron-containing amino acids

• C.C.Cunningham, R.Vegners, R.Bucki, M.Funaki, N.Korde, J.H. Hartwig, Th.P. Stossel, P.A.Janmey.   Cell permanent polyphosphoinositide-binding peptides that block cell motility and actin assembly. -  J. Biol. Chem., 2001,  vol. 276, N 46, pp. 43390-43399.

Born: 1938, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822, 7602346 (home).
Fax: +371 7550338, 7602346 (home).
E-mail: vegners@osi.lv

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• Chemistry, Medicinal & Organic

• G.Veinberg, I.Shestakova, N.Grigan, D.Musel , I.Kanepe, I.Domracheva, V.Grigoryeva , O.Zharkova, I.Turovskis, I.Kalvinsh, A.Strakovs, E.Lukevics. New biological properties of tert-butil cephalosporanate sulfones, Eur. J. Med. Chem., 1998, vol. 33, N 10, pp. 755-762.

Born: 1941, Russia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: veinberg@osi.lv

Home page: click here

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• Chemistry, Medicinal & Organic
• Biophysics and Cell Biology
• Medicine

Recent/Representative Publication

• A.Velena, J.Zilbers, G.Duburs. Derivatives of 1,4-dihydropyridines as modulators of ascorbate-induced lipid peroxidation and high-amplitude swelling of mitochondria, caused by ascorbate, sodium linoleate and sodium pyrophosphate, Cell Biochem. Funct., 1999, vol. 17, pp. 237–252.

Born: 1944, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006
Latvia

Phone: +371 551822. Fax: +371 7550338
E-mail: aiva@osi.lv

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• Chemistry, Medicinal

• Veveris M., Dambrova M., Cirule H., Meirena D., Kalvinsh I., Wikberg J.E.S. Cardioprotective effect of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats, Brit. J. Pharmacol., 1999, vol. 128. pp. 1089–1097.

Born: 1946, Talsi, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7702116 Fax: +371 7550338
E-mail: veveris@osi.lv

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• Chemistry, Medicinal

• A. Krauze, V.Garaliene, R.Vitolina, G.Duburs. Synthesis of 4,5-dipirydin-2(1H)-ones, pyridine-2-(1H)-thiones and related derivatives as analogues of cardiotonic drug milrinone.- Heterocycl. Commun., 2001, Vol. 7, N 5, pp. 427-432.  

Born: 1939, Riga, Latvia

Latvian Institute of Organic Synthesis
Aizkraukles iela 21, Riga LV-1006, Latvia

Phone: +371 7551822. Fax: +371 7550338
E-mail: aiva@osi.lv

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